Darryl Horn, PhD, FAAO

Associate Professor, Salus University


Darryl Horn


  • Post Doctorate, Department of Cancer Biology, Scripps Research Institute
  • PhD, Biochemistry and Molecular Biology, University of Miami Miller School of Medicine
  • MS, Microbiology, University of Wisconsin Oshkosh
  • BS, Biology, University of Wisconsin Stevens Point

Role at Salus University:

  • Director, Post-baccalaureate Program in Health Sciences
  • Assistant Director, Biomedicine Program
  • Associate Professor, Pennsylvania College of Optometry
  • Associate Professor, Basic and Biomedical Sciences
  • Associate Professor, Audiology, Residential Program

Selected Representative Publications:

  • Fontanesi F., Soto I., Horn D., and Barrientos A. Assembly of cytochrome c Oxidase, a complicated and highly regulated process. Am J Cell Physiol. Dec 2006. 291(6):1129-47.
  • Horn D., Al-Ali H., and Barrientos A. Cmc1p is a conserved mitochondrial twin Cx9C protein involved in cytochrome c oxidase biogenesis. Mol Cell Biol. 2008, July. 28(13): 4354-64.
  • Horn D. and Barrientos A. Mitochondrial copper metabolism and delivery to cytochrome c oxidase. IUBMB Life. 2008, July. 60(7): 421-9.
  • Barrientos A, Gouget K, Horn D, Soto IC, and Fontanesi F. Suppression mechanisms of COX assembly defects in yeast and human: Insights into the COX assembly process. Biochim Biophys Acta. 2009 Jan. 1793(1): 97-107.
  • Soto IC, Fontanesi F, Valledor M, Horn D, Singh R, and Barrientos A. Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F(1)F(0)-ATP synthase. Biochim Biophys Acta. 2009 Nov. 1793(11):1776-86.
  • Fontanesi F, Soto I, Horn D, and Barrientos A. Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis. Mol Cell Biol. 2010 Jan; 30(1):245-59
  • Horn D, Zhou W, Trevisson E, Al-Ali H, Harris TK, Salviati L, and Barrientos A. The conserved mitochondrial twin Cx9C protein Cmc2 is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. JBC. 2010. 285:15088-99.
  • Horn D, Mason S, and Karbstein K. Rcl1-A novel nuclease for 18S rRNA production. JBC. 2011 Sept. 286: 34082-87.
  • Neal S, Dabir D, Tienson H, Horn D, Glaeser K Ogozalek Loo R, Barrientos A and Koehler C. Mia40 serves as an electron sink in the Mia40-Erv1 import pathway. JBC. 2015 Aug. 290(34):20804-14.

Professional Activities:

  • Fellow, American Academy of Optometry