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Post Doctorate, Department of Cancer Biology, Scripps Research Institute
PhD, Biochemistry and Molecular Biology, University of Miami Miller School of Medicine
MS, Microbiology, University of Wisconsin Oshkosh
BS, Biology, University of Wisconsin Stevens Point
Role at the University:
Director, Post-baccalaureate Program in Health Sciences
Director, Graduate Programs in Biomedicine
Associate Professor, Pennsylvania College of Optometry
Associate Professor, Basic and Biomedical Sciences
Associate Professor, Audiology, Residential Program
Selected Representative Publications:
Fontanesi F., Soto I., Horn D., and Barrientos A. Assembly of cytochrome c Oxidase, a complicated and highly regulated process. Am J Cell Physiol. Dec 2006. 291(6):1129-47.
Horn D., Al-Ali H., and Barrientos A. Cmc1p is a conserved mitochondrial twin Cx9C protein involved in cytochrome c oxidase biogenesis. Mol Cell Biol. 2008, July. 28(13): 4354-64.
Horn D. and Barrientos A. Mitochondrial copper metabolism and delivery to cytochrome c oxidase. IUBMB Life. 2008, July. 60(7): 421-9.
Barrientos A, Gouget K, Horn D, Soto IC, and Fontanesi F. Suppression mechanisms of COX assembly defects in yeast and human: Insights into the COX assembly process. Biochim Biophys Acta. 2009 Jan. 1793(1): 97-107.
Soto IC, Fontanesi F, Valledor M, Horn D, Singh R, and Barrientos A. Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F(1)F(0)-ATP synthase. Biochim Biophys Acta. 2009 Nov. 1793(11):1776-86.
Fontanesi F, Soto I, Horn D, and Barrientos A. Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis. Mol Cell Biol. 2010 Jan; 30(1):245-59
Horn D, Zhou W, Trevisson E, Al-Ali H, Harris TK, Salviati L, and Barrientos A. The conserved mitochondrial twin Cx9C protein Cmc2 is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. JBC. 2010. 285:15088-99.
Horn D, Mason S, and Karbstein K. Rcl1-A novel nuclease for 18S rRNA production. JBC. 2011 Sept. 286: 34082-87.
Neal S, Dabir D, Tienson H, Horn D, Glaeser K Ogozalek Loo R, Barrientos A and Koehler C. Mia40 serves as an electron sink in the Mia40-Erv1 import pathway. JBC. 2015 Aug. 290(34):20804-14.
